Complementation tagging of cooperating oncogenes in knockout mice

Authors: Allen J.D.; Berns A.

Source: Seminars in Cancer Biology, Volume 7, Number 5, October 1996 , pp. 299-306(8)

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Abstract:

Gene disruption and overexpression in mice can be combined with proviral tagging to investigate the biochemical pathways in which oncogenes act. The phenomenon of oncogene collaboration permits a focussed genetic approach analogous to the strategies employed in suppressor screens in invertebrates and yeast. We illustrate here its application to investigating the action of the pim kinases in tumorigenesis. However, it should be possible to utilize this strategy for dissecting a much wider range of biochemical pathways in mammalian systems.

Keywords: complementation; pim-1

Language: English

Document Type: Miscellaneous

Affiliations: Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands

Publication date: 1996-10-01