Matrix metalloproteinases and tumor invasion: from correlation and causality to the clinic
Authors: Stetler-Stevenson W.G.; Hewitt R.; Corcoran M.
Source: Seminars in Cancer Biology, Volume 7, Number 3, 1996 , pp. 147-154(8)
Publisher: Academic Press
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Abstract:
Tumor cell invasion is now viewed as dysregulated physiologic invasion. Investigators have started to define the molecular events that are involved in this process. We find that there are many functional similarities with molecular events involved in physiologic process such as angiogenesis and wound healing. Matrix metalloproteinase activity is a common denominator in these pathologic conditions and in normal responses. Studies using endogenous metalloproteinase inhibitors suggest that targeting matrix metalloproteinase activity may prevent tumor cell dissemination. The development and pre-clinical testing of novel, low molecular weight matrix metalloproteinase inhibitors support this concept and suggest that an exciting new era of cancer therapy is on the horizon.
Keywords: invasion; metastases; proteases
Language: English
Document Type: Miscellaneous
Affiliations: From the Extracellular Matrix Pathology Section, Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA:
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