Serial Analysis of Gene Expression in Chronic Hepatitis C and Hepatocellular Carcinoma
Authors: Yamashita T.1, 2; Kaneko S.1; Hashimoto S-i.2; Sato T.2; Nagai S.2; Toyoda N.2; Suzuki T.2; Kobayashi K.1; Matsushima K.2
Source: Biochemical and Biophysical Research Communications, Volume 282, Number 2, March 2001 , pp. 647-654(8)
Publisher: Academic Press
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Abstract:
Hepatitis C virus (HCV) causes chronic hepatitis C (CH-C) and is epidemiologically linked with the occurrence of hepatocellular carcinoma (HCC). To elucidate the comprehensive gene expression profiles of CH-C and HCC, serial analysis of gene expression (SAGE) libraries were made from CH-C and HCC tissues of a patient, and compared with a reported SAGE library of a normal liver (NL). Scatter plots of the distribution of tags from the HCC library exhibited the existence of many differentially expressed genes compared with those from the CH-C and NL libraries. Up-regulation of IFN-gamma inducible genes and oxidative stress-inducible genes were identified in both the CH-C and HCC libraries, and some unpublished new genes were specifically up- or down-regulated in the HCC library. This genome-wide scanning study discloses the molecular portraits of CH-C and HCC, and provides novel candidate genes that should help clarify the mechanism of hepatocarcinogenesis in the chronically HCV-infected liver. Copyright 2001 Academic Press.
Keywords: chronic hepatitis C; gene expression profile; hepatocellular carcinoma; hepatitis C virus; serial analysis of gene expression; transcriptome
Language: English
Document Type: Research article
Affiliations: 1: First Department of Internal Medicine & CREST, Kanazawa University School of Medicine, Kanazawa, 920-8641, Japan 2: School of Medicine, University of Tokyo, Tokyo, 113-0033, Japan
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