Increase in the Concentration of Carbon 18 Monounsaturated Fatty Acids in the Liver with Hepatitis C: Analysis in Transgenic Mice and Humans

Authors: Moriya K.¹; Todoroki T.³; Tsutsumi T.^{1, 4}; Fujie H.¹; Shintani Y.¹; Miyoshi H.¹; Ishibashi K.⁵; Takayama T.²; Makuuchi M.²; Watanabe K.³; Miyamura T.⁴; Kimura S.¹; Koike K.¹

Source: Biochemical and Biophysical Research Communications, Volume 281, Number 5, March 2001 , pp. 1207-1212(6)

Publisher: Academic Press

Abstract:

Steatosis is one of the histologic characteristics of chronic hepatitis C and is well reproduced in a transgenic mouse model for hepatocellular carcinoma (HCC) in which the core protein of hepatitis C virus (HCV) plays a pivotal role in inducing steatosis and HCC. In the present study, the lipid composition in the liver of the HCV core gene transgenic mice as well as in those of chronic hepatitis C patients was determined. The concentration of carbon 18 monounsaturated (C18:1) fatty acids, such as oleic and vaccenic acids, which are known to increase membrane fluidity leading to higher cell division rates, significantly increased in the livers of transgenic mice compared to nontransgenic control mice. The concentration of C18:1 fatty acids also significantly increased in the livers of chronic hepatitis C patients compared to subjects without HCV infection. These results suggest that HCV may affect a specific pathway in the lipid metabolism and cause steatosis in the liver. Copyright 2001 Academic Press.

Keywords: steatosis; oleic acid; core protein; hepatocellular carcinoma

Language: English

Document Type: Research article

Affiliations: 1: Department of Internal Medicine 2: Department of Internal Medicine, Department of Hepatobiliary, Pancreatic, and Transplantation Surgery, University of Tokyo, Tokyo, Japan 3: Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan 4: Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan 5: Daiichi Pharmaceuticals, Tokyo, Japan

Publication date: 2001-03-01

• In this: publication
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• In this Subject: Anatomy & Physiology ,  Biology ,  Biochemistry
• By this author: Moriya K. ;  Todoroki T. ;  Tsutsumi T. ;  Fujie H. ;  Shintani Y. ;  Miyoshi H. ;  Ishibashi K. ;  Takayama T. ;  Makuuchi M. ;  Watanabe K. ;  Miyamura T. ;  Kimura S. ;  Koike K.

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