Insulinomimetic bis(maltolato)zinc(II) Complex: Blood Glucose Normalizing Effect in KK-Ay Mice with Type 2 Diabetes Mellitus

Authors: Yoshikawa Y.1; Ueda E.1; Miyake H.1; Sakurai H.2; Kojima Y.1

Source: Biochemical and Biophysical Research Communications, Volume 281, Number 5, March 2001 , pp. 1190-1193(4)

Publisher: Academic Press

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

High blood glucose levels of KK-Ay mice with type 2 diabetes mellitus were normalized by daily intraperitoneal (ip) administration of a zinc(II) complex, bis(maltolato)zinc(II) (Zn(Mal)2) with a Zn(O4) coordination mode, following the finding of strong in vitro insulinomimetic activity in isolated rat adipocytes treated with epinephrine in terms of the inhibition of free fatty acid release. The blood glucose level was maintained in the normal range during administration of the Zn(Mal)2 complex for 14 days and improvements in the glucose tolerance were confirmed by an oral glucose tolerance test. Copyright 2001 Academic Press.

Keywords: zinc complex; KK-Ay mice; blood glucose normalizing effect

Language: English

Document Type: Research article

Affiliations: 1: Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka, 558-8585, Japan 2: Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto, 607-8414, Japan

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$54.13 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A