IngentaConnect Ghrelin Stimulates Gastric Acid Secretion and Motility in Rats

Authors: Masuda Y.¹; Tanaka T.¹; Inomata N.¹; Ohnuma N.¹; Tanaka S.¹; Itoh Z.¹; Hosoda H.²; Kojima M.²; Kangawa K.²

Source: Biochemical and Biophysical Research Communications, Volume 276, Number 3, October 2000 , pp. 905-908(4)

Abstract:

Ghrelin, a novel growth-hormone-releasing peptide, was discovered in rat and human stomach tissues. However, its physiological and pharmacological actions in the gastric function remain to be determined. Therefore, we studied the effects of rat ghrelin on gastric functions in urethane-anesthetized rats. Intravenous administrations of rat ghrelin at 0.8 to 20 g/kg dose-dependently increased not only gastric acid secretion measured by a lumen-perfused method, but also gastric motility measured by a miniature balloon method. The maximum response in gastric acid secretion was almost equipotent to that of histamine (3 mg/kg, i.v.). Moreover, these actions were abolished by pretreatment with either atropine (1 mg/kg, s.c.) or bilateral cervical vagotomy, but not by a histamine H₂-receptor antagonist (famotidine, 1 mg/kg, s.c.). These results taken together suggest that ghrelin may play a physiological role in the vagal control of gastric function in rats. Copyright 2000 Academic Press.

Keywords: ghrelin; growth-hormone secretagogues; GHS-R; stomach; gastric acid; gastric motility; vagal nerve; rat; growth hormone

Language: English

Document Type: Research article

Affiliations: 1: Suntory Institute for Medicinal Research & Development, 2716-1 Kurakake, Akaiwa, Chiyoda-machi, Ohra-gun, Gunma, 370-0503, Japan 2: Department of Biochemistry, National Cardiovascular Center Research Institute, Fujishirodai, Suita, Osaka, 565-8565, Japan

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