N6-Furfuryladenine, Kinetin, Protects against Fenton Reaction-Mediated Oxidative Damage to DNA

Authors: Olsen A.; Siboska G.E.; Clark B.F.C.; Rattan S.I.S.

Source: Biochemical and Biophysical Research Communications, Volume 265, Number 2, November 1999 , pp. 499-502(4)

Publisher: Academic Press

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Abstract:

N6-Furfuryladenine (kinetin) has been shown to have anti-ageing effects on several different systems including plants, human cells in culture, and fruitflies. Since most of the experimental data point toward kinetin acting as an antioxidant both in vitro and in vivo, and since much evidence supporting a causal role of oxidative damage in ageing is accumulating, we tested the antioxidant properties of kinetin directly. Using 8-oxo-2primedeoxyguanosine (8-oxo-dG) in calf thymus DNA as a marker for oxidative damage, we demonstrate that kinetin significantly (P < 0.005) protects the DNA against oxidative damage mediated by the Fenton reaction. Kinetin inhibited 8-oxo-dG formation in a dose-dependent manner with a maximum of 50% protection observed at 100 muM kinetin. Copyright 1999 Academic Press.

Language: English

Document Type: Research article

Affiliations: Department of Molecular and Structural Biology, University of Aarhus, Gustav Wieds Vej 10-C, Aarhus, DK-8000, Denmark:

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