Phosphatidylethanolamine N-Methyltransferase 2 and CTP-Phosphocholine Cytidylyltransferase Expressions Are Related with Protein Kinase C Isozymes in Developmental Liver Growth

Authors: Sesca E.¹; Perletti G.P.²; Binasco V.¹; Chiara M.¹; Tessitore L.¹

Source: Biochemical and Biophysical Research Communications, Volume 229, Number 1, December 1996 , pp. 158-162(5)

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Abstract:

PEMT and CT activities were reciprocally regulated during the perinatal period. Consistently, PEMT2 expression was undetectable before birth when CT was highly expressed. Surprisingly, PEMT2 was relatively highly expressed at birth when the cell division and CT expression were still high. During development liver cell growth was associated with enhanced levels in the activity of beta, zeta and, particularly, alpha PKC. The activity of deltaPKC was lower in foetal, higher in the newborn and again slightly lower than adult liver 10 days after birth. These data show that CT expression and alpha, beta and zeta PKC activities are positively, whereas PEMT2 expression and delta PKC activity are negatively associated with the liver cell division during development.

Language: English

Document Type: Research article

Affiliations: 1: Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi di Torino, Turin, Italy 2: Istituto di Farmacologia, Universita degli Studi di Milano, Milan, Italy

Publication date: 1996-12-01