The Anti-HIV Activity and Mechanisms of Action of Pure Compounds Isolated from Rosa damascena

Authors: Mahmood N.¹; Piacente S.²; Pizza C.²; Burke A.¹; Khan A.I.¹; Hay A.J.³

Source: Biochemical and Biophysical Research Communications, Volume 229, Number 1, December 1996 , pp. 73-79(7)

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Abstract:

Water and methanol extracts of Rosa damascena exhibited moderate anti-HIV activity. The anti-viral activities of 9 compounds isolated from the methanol extract were compared. The tetrahydroxyflavanone (kaempferol, 1 ), was effective in reducing the maturation of infectious progeny virus apparently due to selective inhibition of the viral protease. On the other hand the pentahydroxyflavone (quercetin, 2 ) and two 3 -substituted derivatives of kaempferol appeared to inhibit HIV-infection by preventing binding of gp120 to CD4. 2-Phenylethanol-O-(6-O-galloyl)-beta-D-glucopyranoside 8 interacted irreversibly with gp120 and neutralized virus infectivity. The differences in the modes of action of 1 and 8 can account for the apparent synergy of their anti-viral activities.

Language: English

Document Type: Research article

Affiliations: 1: MRC Collaborative Centre, 1-3 Burtonhole Lane, Mill Hill, London, NW7 1AD, United Kingdom 2: Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Piazza V. Emanuele 9, Penta di Fisciano (SA), 84084, Italy 3: National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom

Publication date: 1996-12-01