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Geranylgeraniol Causes a Decrease in Levels of Calreticulin and Tyrosine Phosphorylation of a 36-kDa Protein Prior to the Appearance of Apoptotic Features in HL-60 Cells

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It was demonstrated recently that geranylgeraniol (GGO) has potent apoptosis-inducing activity in various lines of tumor cells, including HL-60 cells. In the present study, we found that GGO markedly inhibited the expression of a calcium-binding protein, calreticulin, prior to the induction of apoptosis in HL-60 cells. Furthermore, we also observed a significant decrease in the tyrosine phosphorylation of a 36-kDa protein that is a major tyrosine-phosphorylated protein in HL-60 cells. These findings suggest that decreases in levels of calreticulin and in the tyrosine phosphorylation of the 36-kDa protein might be associated with the induction of apoptosis by GGO in HL-60 cells.

Document Type: Research Article

Affiliations: 1: School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142, Japan 2: Products Formulation Research Laboratory, Eisai Co., Ltd., 2-3-14 Minami, Honjo, Saitama, 367, Japan

Publication date: September 1, 1996

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