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Cloning of the Rho B Gene from the Mouse Genome and Characterization of Its Promoter Region

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Abstract:

Rho proteins have been implicated in a variety of cytoskeletal functions, but it is unclear how Rho proteins regulate these cellular functions and how Rho proteins are regulated. In this study, we cloned the rho B gene from the mouse genome and characterized its promoter region. The predicted amino acid sequence was identical to that encoded by the human rho B gene. A site for initiation of transcription was found at position -376 relative to the site for initiation of translation. Deletion analysis of the 5\'-flanking region of the rho B gene revealed that the minimum region of the promoter was located between positions -507 and -376. Northern blotting analysis showed that the expression of the mouse rho B gene was induced by serum, suggesting that expression of the rho B gene might be controlled by some signal-responsive element(s).

Document Type: Research Article

Affiliations: 1: Banyu Tsukuba Research Institute in Collaboration with Merck Research Laboratories, Okubo 3, Tsukuba, 300-26, Japan 2: Biology Division, National Cancer Center Research Institute, Tsukiji 5-1-1, Chuo-ku, Tokyo, 104, Japan

Publication date: September 1, 1996

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