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Inhibition of Alzheimer's Amyloidosis by Peptides That Prevent beta-Sheet Conformation

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Abstract:

Amyloid beta-peptide (Abeta) is a major fibrillar component of neuritic plaques in Alzheimer's disease (AD) brains and is related to the pathogenesis of the disease. We hypothesized that amyloid formation could be inhibited by peptides homologous to Abeta (position 17-21) with a similar degree of hydrophobicity, but with a very low propensity to adopt a beta-sheet conformation by incorporating proline residues (anti-beta-sheet peptides or beta-sheet inhibitors). An 11-residue peptide with these characteristics binds to Abeta, inhibits Abeta fibril formation and partially disaggregates preformed fibrils in vitro. Shorter anti-beta-sheet peptides and analogs containing D-amino acids are also able to inhibit Abeta fibrillogenesis. The latter are more resistant to proteolytic degradation and may serve as a starting point to design more efficient peptides derivatives to inhibit amyloidogenesis in vivo.

Document Type: Research Article

Affiliations: 1: Department of Neurology, New York University Medical Center, 550 First Avenue, New York, New York, 10016 2: Department of Biochemistry, University of Kentucky, Lexington, Kentucky 3: Department of Pathology, New York University Medical Center, 550 First Avenue, New York, New York, 10016

Publication date: September 1, 1996

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