Mitochondrial Nitric Oxide Synthase: A Ubiquitous Regulator of Oxidative Phosphorylation?

Authors: Bates, T.E.1; Loesch, A.2; Burnstock, G.2; Clark, J.B.1

Source: Biochemical and Biophysical Research Communications, Volume 218, Number 1, January 1996 , pp. 40-44(5)

Publisher: Academic Press

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In this article we demonstrate the immunocytochemical localization of nitric oxide synthase in mitochondria isolated from heart, skeletal muscle, and kidney, using a monoclonal antibody directed against the endothelial form of nitric oxide synthase. The possibility that mitochondrially located nitric oxide synthase is a ubiquitous regulator of mitochondrial oxidative phosphorylation in mammalian cells is discussed.

Document Type: Research Article

Affiliations: 1: Institute of Neurology, University of London, Queen Square, London, WC1N 3BG, England 2: Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, England

Publication date: January 1, 1996

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