IngentaConnect The Neural Correlates of Aversive Auditory Stimulation

Authors: Zald D.H.¹; Pardo J.V.^{2, 3}

Source: NeuroImage, Volume 16, Number 3a, July 2002 , pp. 746-753(8)

Abstract:

Previous neuroimaging studies indicate that the human amygdala activates during exposure to aversive visual, olfactory and gustatory stimuli. To examine amygdala responses to aversive auditory stimuli, we exposed healthy human subjects to unpleasant sounds while regional cerebral blood flow (rCBF) was assayed with O-15 PET. Eight subjects, all of whom described themselves as reactive to aversive sounds, participated in the study. Relative to white noise, the aversive sounds produced significant rCBF increases in the lateral amygdala/claustrum region. Significant activations also localized to the dorsal brainstem, medial temporal pole, basal forebrain (nucleus accumbens), insula, right auditory association cortices, putamen, thalamus and cerebellum. These data indicate that the amygdala responds to aversive auditory stimuli in a manner similar to its response to unpleasant stimuli in other sensory modalities. The data further highlight a widely distributed network of cortical and subcortical areas activated during exposure to aversive sounds. © 2002 Elsevier Science (USA).

Keywords: auditory; amygdala; emotion; human; neuroimaging; positron emission tomography; temporal pole; periaqueductal gray

Language: English

Document Type: Research article

DOI: 10.1006/nimg.2002.1115

Affiliations: 1: Department of Psychology, Vanderbilt University, Nashville, Tennessee, 37240 2: Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, Minnesota, 55417 3: Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, 55455

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