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T1Effects in Sequential Dynamic Susceptibility Contrast Experiments

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Residual effects of an initial bolus of gadolinium contrast agent have been previously demonstrated in sequential dynamic susceptibility contrast MR experiments. While these residual effects quickly reach a saturation steady state, their etiology is uncertain, and they can lead to spurious estimates of hemodynamic parameters in activation experiments. The possible influence ofT1effects is now investigated with experiments in whichT1weighting is varied as well as with serial regionalT1measurements. Little evidence for significant residualT1effects is found, suggesting instead that susceptibility effects underlie these observations. An initial saturation dose of contrast agent minimizes this effect.

Keywords: cerebral blood volume; contrast agents; fMRI; relaxation time; susceptibility contrast

Document Type: Research Article

Affiliations: McLean Hospital, Harvard Medical School, Belmont, Massachusetts, 02178

Publication date: February 1, 1998

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