Functional Continuum of Regulatory Peptides (RPs): Vector Model of RP-Effects Representation

Authors: KOROLEVA S.V.; ASHMARIN I.P.

Source: Journal of Theoretical Biology, Volume 216, Number 3, June 2002 , pp. 257-271(15)

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Abstract:

During the past decades, bioactive (regulatory) peptides have been identified as the major players in the regulation of many important biological processes. Dozens of peptides have found their application as pharmaceutical agents, which further stimulated research in this field making it one of the most rapidly developing areas on the edge of biological science and medicine. However, the fast accumulation of enormous amounts of experimental data has revealed a great difficulty in their analysis and demanded the development of a systematic approach for generalization of the obtained information. We propose a new computer-based algorithm for studying biological activities of regulatory peptides and their groups based on their representation as vectors in n -dimensional functional space. Our method allows the rapid analysis of databases containing thousands of polyfunctional regulatory peptides with overlapping spectra of physiological activity. The described method permits to perform several types of correlations which, when applied to the large databases, could reveal new important information about the system of regulatory peptides. It can select the groups of peptides with similar physiological role (peptide constellations) and search for the optimal peptide combinations with predetermined spectrum of effects and minimal side effects for their further pharmacological application. It can also reveal the role of regulatory peptides in induction of chain physiological reactions.Copyright 2002 Elsevier Science Ltd. All rights reserved.

Language: English

Document Type: Research article

Affiliations: Department of Biology, Moscow State University, Vorobievy Gory, Moscow, 119899, Russia

Publication date: 2002-06-01