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A BAC Contig Map of the Ly49 Gene Cluster in 129 Mice Reveals Extensive Differences in Gene Content Relative to C57BL/6 Mice

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The murine Ly49 gene family is functionally analogous to the human killer cell Ig-like receptor (KIR) family of class I major histocompatibility complex (MHC) receptors. The number of KIR genes varies dramatically between individuals; however, the organization of the Ly49 genes has only been determined for the C57BL/6 (B6) mouse. The organization of the 129 Ly49 loci was determined from a BAC contig map by PCR and Southern blot analysis. In addition to the 10 Ly49 genes known from previous studies of the 129/J strain, 8 new genes were localized to the 129 Ly49 cluster. A gene order of Ly49q1, e, (v, q2), e/c2, l/r, s, t, e/c1, r, u, u/i, i1, g, p/d, (i2, p), and o was determined. The 129 Ly49 gene cluster is predicted to span ∼600 kb. These results indicate that Ly49 gene numbers can be significantly different between inbred mouse strains, analogous to the haplotype differences observed in the human KIR genes.

Document Type: Research Article

DOI: http://dx.doi.org/10.1006/geno.2002.6724

Affiliations: 1: Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute–Frederick, Frederick, Maryland, 21702-1201, USA 2: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA 3: Intramural Research Support Program, SAIC–Frederick, National Cancer Institute–Frederick, Frederick, Maryland, 21702-1201, USA

Publication date: March 1, 2002

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