IngentaConnect Cloning of a Novel Human Putative Type Ia Integral Membrane Prote...

Authors: Yaspo M.L.¹; Aaltonen J.²; Horelli-Kuitunen N.³; Peltonen L.²; Lehrach H.¹

Source: Genomics, Volume 49, Number 1, April 1998 , pp. 133-136(4)

Abstract:

The distal part of human chromosome 21q22.3 is exceptionally gene rich and contains several loci that have been linked to hereditary disorders. In the course of constructing an extensive transcript map for chromosome 21, we have isolated numerous coding segments in 21q22.3 that represent potential candidate genes in this region. Following this approach, we have cloned a novel single-copy gene (C21orf3) (HGMW-approved symbol C21orf1) expressed as a unique 2.69-kb mRNA in a wide range of tissues. We have precisely mapped C21orf3 by fiber FISH distal to marker D21S171. The C21orf3 gene encodes a predicted protein of 180 residues that does not share any sequence homology with other known proteins. C21orf3 harbors predicted structural features of a type Ia integral membrane protein and contains a tetrapeptide motif (YXRF) observed in several cell surface proteins involved in signal transduction. Although the function of C21orf3 is still unknown, this novel gene may play an important role in a cell trafficking mechanism. Copyright 1998 Academic Press.

Language: English

Document Type: Short communication

Affiliations: 1: Max Planck Institute fuer Molekulare Genetik, Ihnestrasse 73, Berlin, D-14195, Germany 2: Department of Human Molecular Genetics, National Public Health Institute, Mannerheimintie 166, Helsinki, 00300, Finland 3: Department of Clinical Chemistry and Department of Biomedicine, University of Helsinki, Haartmaninkatu 4, Helsinki, 00290, Finland

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Cloning of a Novel Human Putative Type Ia Integral Membrane Protein Mapping to 21q22.3