COMPARATIVE ANTI-NOCICEPTIVE, ANTI-INFLAMMATORY AND TOXICITY PROFILE OF NIMESULIDE vs NIMESULIDE AND PIPERINE COMBINATION

Authors: GUPTA S.K.; BANSAL P.; BHARDWAJ R.K.; VELPANDIAN T.

Source: Pharmacological Research, Volume 41, Number 6, June 2000 , pp. 657-662(6)

Publisher: Academic Press

Abstract:

Piperine is an inhibitor of various hepatic and other enzymes involved in the biotransformation of drugs. Preliminary pharmacokinetic studies conducted by us suggested the increased bioavailability of nimesulide co-administered with piperine. The present study was, thus, conducted to evaluate the antinociceptive, anti-inflammatory and toxicity profile of a new nimesulide–piperine combination administered orally as compared with nimesulide alone. Antinociceptive efficacy was tested using an acetic acid writhing test and tail flick latency test (TFL). The ED50 value of a nimesulide–piperine combination in writhing test was calculated to be significantly lower (1.5 mg kg^-1) as compared to (11.2 mg kg^-1) of nimesulide alone. The antinociceptive effect was lesser in the tail flick latency test as compared to what was observed in the writhing test indicating the peripheral action of the Non-Steriodal Anti-Inflammatory Drug (NSAID). In carrageenan-induced inflammatory tests, the nimesulide–piperine combination was found to be dose-to-dose superior than nimesulide alone. Acute toxicity studies on mice revealed a reduction in lethal dose (LD50) of the combination (980 mg kg^-1) as compared to nimesulide (1500 mg kg^-1) alone. Results from the present study suggest a better therapeutic index for the nimesulide–piperine combination indicating that this combination would further reduce the frequency of adverse effects associated with nimesulide alone.Copyright 2000 Academic Press

Language: English

Document Type: Research article

Affiliations: Department of Pharmacology,, All India Institute of Medical Sciences,, New Delhi, 110029,, India

Publication date: 2000-06-01

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