CHANGES IN MONOAMINE METABOLITES CONCENTRATIONS IN RAT CEREBROSPINAL FLUID AFTER ACUTE AND LONG-TERM ADMINISTRATION OF A SELECTIVE SEROTONIN REUPTAKE INHIBITOR, TRAZODONE
Authors: EGASHIRA T.; TAKAYAMA F.; YAMANAKA Y.
Source: Pharmacological Research, Volume 40, Number 6, December 1999 , pp. 503-508(6)
Publisher: Academic Press
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Abstract:
In order to clarify the mechanism of the antidepressive effects of trazodone, a selective serotonin reuptake inhibitor, we investigated the dynamics of monoamine metabolites in cerebrospinal fluid (CSF) of free-moving conscious rats by acute and long-term treatment with trazodone. When 100 mg kg-1p.o. of trazodone were administered, a significant increase of 3-methoxy-4-hydroxyphenylglycol (MHPG) concentration was soon observed in the light period of the light/dark cycle, and a significant decrease of dihydroxy phenyl acetic acid (DOPAC) concentration was observed during the 2 days after administration of trazodone; in contrast, the homovanilic acid (HVA) level was increased. However, we detected no significant changes in the 5-hydroxy indole-3-acetic acid (5-HIAA) concentration during the 3 days. In the case of long-term treatment with 50 mg kg-1, p.o. of trazodone, the levels of MHPG, DOPAC and HVA exhibited no difference when compared with values obtained during saline treatment in either the light or dark period, whereas the levels of 5-HIAA showed a significant increase during the light period. These findings suggest that a long-term treatment with trazodone enhances the serotonergic neurons.pc 1999 Academic Press@p$hr Copyright 1999 Academic Press
Language: English
Document Type: Research article
Affiliations: Department of Pharmacology,, Oita Medical University,, 1-1, Idaigaoka,, Hasama-machi,, Oita, 879-5593,, Japan:
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