PHARMACODYNAMIC MODELLING OF LEVODOPA, 3-O-METHYLDOPA AND THEIR EFFECTS: AN APPLICATION OF THE DIXON EQUATION

Authors: WU G.; FURLANUT M.

Source: Pharmacological Research, Volume 39, Number 3, January 1999 , pp. 203-210(8)

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Abstract:

The modified Dixon equation was applied to describe the relationship between levodopa, 3- O -methyldopa (3OMD) concentrations and tapping test in 16 patients with Parkinson's disease treated with controlled release levodopa/carbidopa association. The sigmoid equation was also used to describe the relationship between levodopa and tapping test, and the results were compared to those obtained using the Dixon equation. Graphically, the fittings using the Dixon equation can be constructed in a three-dimensional space, whereas the fittings using the sigmoid equation can be constructed in a two-dimensional plane. The results show that the fittings in the three-dimensional space are slightly better than those in the two-dimensional plane. The advantage of the Dixon equation over the sigmoid equation is that the Dixon equation can take 3OMD into consideration for pharmacodynamic modelling.Copyright 1999 The Italian Pharmacological Society

Language: English

Document Type: Research article

Affiliations: Institute of Clinical Pharmacology and Toxicology, Chair of Special Pharmacology, Medical School, University of Udine, P.le S. Maria della Misericordia, Udine, 33100, Italy

Publication date: 1999-01-01