Predicting the distribution, conservation, and functions of SNAREs and related proteins in fungi

In this: publication
By this: publisher
In this Subject: Botany
By this author: Gupta G.D. ;&nbsp; Brent Heath I.

Authors: Gupta G.D.; Brent Heath I.

Source: Fungal Genetics and Biology, Volume 36, Number 1, June 2002 , pp. 1-21(21)

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Abstract:

Hyphal tip growth, the hallmark of the fungi, requires highly polarized and localized exocytosis, but how this requirement is met is unknown. Members of conserved protein families called SNAREs and Rabs mediate vesicle trafficking and fusion at virtually every step of the intracellular pathway in all examined eukaryotes. We have searched the available nearly complete fungal genomes, established the presence or absence of members of the SNARE and Rab families in these genomes, and predicted their evolutionary relationships to one another. Comparisons with the extensively studiedSaccharomyces cerevisiae indicate that, in general, most of the members of these families (including those involved in mediating exocytosis) are conserved. The presence of exceptional SNAREs and Rabs in some fungi that are not conserved in S. cerevisiae may be indicative of specialized steps that occur in these fungi. The implications of these findings for current tip growth models are discussed.

Language: English

Document Type: Research article

Publication date: 2002-06-01