Genetic Polymorphisms in Human Drug Metabolic Enzymes

Authors: Miller M.S.¹; McCarver D.G.²; Bell D.A.³; Eaton D.L.⁵; Goldstein J.A.⁴

Source: Fundamental and Applied Toxicology, Volume 40, Number 1, November 1997 , pp. 1-14(14)

Publisher: Academic Press

Abstract:

Results obtained from both epidemiologic studies and experimental animal model systems have shown a wide range of phenotypic variation in the ability of individuals to metabolize drugs and environmental chemicals. Several studies have noted correlations between specific metabolic phenotypes and the incidence of disease, suggesting that certain allelic forms of drug metabolic enzymes can render the individual either more sensitive or resistant to the toxic or therapeutic effects of exogenous drugs and chemicals. While some of this variation can be attributed to different environmental exposures, it has become clear that genetic factors also play an important role in determining the response of the individual organism to exogenous agents. Recent advances in molecular biological techniques have begun to allow scientists to correlate observed phenotypic differences with the actual differences in genetic sequence at the gene level. This has allowed a correlation between gene structure and function, thus providing a mechanistic basis to explain the interaction between genetic background and individual response to environmental exposures. Results presented at this symposium discussed how genetic polymorphisms for both Phase I and Phase II metabolic enzymes in the human population modulate the response to environmental toxicants. Copyright 1997 Society of Toxicology.

Language: English

Document Type: Miscellaneous

Affiliations: 1: Bowman Gray School of Medicine, Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina, 27157 2: Children's Hospital of Michigan, Wayne State University, Detroit, Michigan, 48201 3: Laboratory of Biochemical Risk Analysis 4: Laboratory of Biochemical Risk Analysis, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27709 5: Department of Environmental Health, University of Washington, Seattle, Washington, 98105-6099

Publication date: 1997-11-01

• In this: publication
• By this: publisher
• In this Subject: Ecology ,  Toxicology
• By this author: Miller M.S. ;  McCarver D.G. ;  Bell D.A. ;  Eaton D.L. ;  Goldstein J.A.

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