A Comparison of the Acute Behavioral Effects of Inhaled Amyl, Ethyl, and Butyl Acetate in Mice

Authors: Bowen S.E.; Balster R.L.

Source: Fundamental and Applied Toxicology, Volume 35, Number 2, February 1997 , pp. 189-196(8)

Buy & download fulltext article:

Price: $52.63 plus tax (Refund Policy)

Abstract:

The acute neurobehavioral effects of three acetates (amyl, ethyl, and n -butyl acetate) were investigated after 20-min inhalation exposures in mice using locomotor activity and a functional observational battery (FOB). Ethyl and n -butyl acetate produced significant decreases in locomotor activity at the highest concentrations examined, while amyl acetate was without effect. Minimally effective concentrations for activity-decreasing effects were 2000 ppm for ethyl acetate and 8000 ppm for n -butyl acetate. The potency order was similar in the FOB where ethyl acetate was more potent in disrupting the neurobehavioral measures. The FOB profile of effects for all three acetates included changes in posture, decreased arousal, increased tonic/clonic movements, disturbances in gait, delayed righting reflexes, and increased sensorimotor reactivity. Furthermore, handling-induced convulsions were produced in some mice acutely exposed to each of these acetates. Recovery from the acute effects of these acetates was rapid and began within minutes of removal from the exposure chamber. The acetates produced a profile of neurobehavioral effects that were different from those reported for depressant solvents (i.e., toluene, 1,1,1-trichloroethane) that are subject to abuse. Evidence is emerging for qualitative differences in the acute neurobehavioral effects of various volatile chemicals.

Language: English

Document Type: Research article

Affiliations: Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, 23298-0613

Publication date: 1997-02-01