Thyroid Cryotherapy in an Experimental Rat Model

Authors: Pomorski L.¹; Bartos M.¹; Matejkowska M.²; Amsolik M.¹; Kuzdak K.¹

Source: Cryobiology, Volume 39, Number 3, November 1999 , pp. 262-270(9)

Publisher: Academic Press

Abstract:

In recent years cryotherapy has been more and more frequently used for the treatment of tumors of different organs. Until now, the use of cryotherapy for the treatment of thyroid lesions, as well as histopathologic changes in thyroid tissue after cryotherapy, has not been described. Nitrous oxide cryotherapy of one thyroid lobe in twenty 12-week male Wistar rats was performed. After 2 and 4 weeks, the cryotreated thyroid lobe and the second lobe along with a part of the trachea, esophagus, and the subhyoid muscles adhering to the thyroid were excised and assessed macro- and microscopically. The macroscopic evaluation, performed 2 and 4 weeks postcryotherapy, revealed atrophy of the cryotreated lobe in 4 and 3 rats, respectively, and reduction of the cryotreated lobe dimensions in 6 and 7 rats, respectively. In the specimens of the lobes excised 2 weeks following cryotherapy, examined microscopically, necrosis, granulomatous inflammation, hemorrhages, and hemosiderin deposits were found most often, whereas in the specimens of the lobe excised after 4 weeks lymphocytic inflammation and fibrosis were mainly observed. No microscopic changes were observed in the thyroid lobes that were not frozen or in the parathyroid glands located inside these lobes or extrathyroidally, either ipsilaterally or contralaterally to the cryotreated thyroid lobes. There was no microscopic damage to other tissues adjacent to the thyroid gland. No rat developed vocal cord dysfunction after cryotherapy and no significant changes in serum calcium level before and after cryotherapy were observed. The results obtained show that it is possible to cryoblate thyroid tissue without damaging the tissues adjacent to the thyroid, as well as to spare function of the recurrent laryngeal nerves and parathyroid glands. Copyright 1999 Academic Press.

Language: English

Document Type: Research article

Affiliations: 1: Institute of Endocrinology, Medical University of Lodz 2: Department of Pathomorphology, Copernicus Hospital of Lodz, Lodz, 93-513, Poland

Publication date: 1999-11-01

• In this: publication
• By this: publisher
• In this Subject: Anatomy & Physiology ,  Chemical Engineering
• By this author: Pomorski L. ;  Bartos M. ;  Matejkowska M. ;  Amsolik M. ;  Kuzdak K.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers