Preparation of Silica Particles Encapsulating Retinol Using O/W/O Multiple Emulsions

Authors: Lee M-H.¹; Oh S-G.¹; Moon S-K.¹; Bae S-Y.²

Source: Journal of Colloid and Interface Science, Volume 240, Number 1, August 2001 , pp. 83-89(7)

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Abstract:

Retinol, a cosmetic ingredient, was entrapped within inorganic microspheres obtained from sol–gel reaction of TEOS in o/w/o multiple emulsions as microreactors. In o/w/o multiple emulsions, the retinol was emulsified as an internal oil phase in a aqueous solution of 3.0 wt% Tween 20 prior to emulsification into an external oil phase. The multiple emulsions appeared to be stable enough in the presence of HPC polymer in the external oil phase. In sol–gel reaction, the hydrolysis and condensation rate of TEOS were greatly dependent upon the catalyst and the molar ratio of H₂O to TEOS (R_W). In this study, sphere-like microspheres entrapping retinol were best formed with the addition of NH₄OH as a catalyst when the concentration of TEOS was at the R_W value of 4. Microspheres obtained under these conditions were 15–40 m with very dense surfaces containing a few globules 1.17–2.35 m. Also, they showed the slower release of retinol into the external ethanol phase and higher loading and encapsulation efficiency. Copyright 2001 Academic Press.

Language: English

Document Type: Research article

Affiliations: 1: Department of Chemical Engineering and CPRC, Hanyang University, Seoul, 133-791, Korea 2: Department of Chemical Engineering, Hanyang University, Kyunggi-do, Ansan-si, 425-791, Korea

Publication date: 2001-08-01