Authors: Cernia E.; Delfini M.; Di Cocco E.; Palocci C.; Soro S.
Source: Bioorganic Chemistry, Volume 30, Number 4, August 2002 , pp. 276-284(9)
Publisher: Academic Press
Abstract:
(±)-2-(6-Methoxy-2-naphthyl)propionic acid methyl ester (methyl ester of Naproxen), the precursor of therapeutically important nonsteroidal anti-inflammatory drugs (NSAIDs) was enantioselectively hydrolysed using as biocatalyst Candida rugosa lipase. In research aimed at studing the structure–activity relationship (SAR), NMR spectroscopy methods were employed to identify which Naproxen molecular moiety was essential to the substrate–enzyme interaction. The experimental results, in agreement with previous computer modelling studies and reported kinetic data, gave new information on the enzyme–substrate complex formation in solution.
© 2002 Elsevier Science (USA)
Language: English
Document Type: Research article
DOI: 10.1016/S0045-2068(02)00014-7
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