Anaerobic Bacteriology in 75 Cases of Thoracic Empyema in Sofia, Bulgaria

Authors: Boyanova L.¹; Petrov D.²; Osmanliev D.³; Mitov I.¹; Usunova I.³; Minchev T.²; Goranov E.²; Plochev M.²; Dimitrov J.³

Source: Anaerobe, Volume 6, Number 2, April 2000 , pp. 81-85(5)

Publisher: Academic Press

Abstract:

The aim of this study was to evaluate the prevalence of anaerobes in patients with thoracic empyema over a period of 30 months and to assess the susceptibility of the isolates to penicillin, clindamycin and metronidazole. Seventy-nine pleural fluid specimens were obtained from 75 adult patients with empyema. Anaerobic isolates were identified by Crystal anaerobes identification system and routine methods. Susceptibility testing was conducted using broth microdilution method and limited agar dilution test. Anaerobic bacteria were found in 50 (66.7%) of the patients and included 96 isolates representing 16 genera. The predominant Gram-positive anaerobes were Peptostreptococcus species (19 isolates) and Streptococcus intermedius (10), and the commonest Gram-negative species were Fusobacterium nuleatum (13),Fusobacterium necrophorum (6) and Prevotella inermedia (3). From two to four anaerobes per specimen were present in 57.4% of the specimens yielding anaerobic bacteria. The susceptibility of the Gram-negative anaerobic isolates to penicillin and that of the Gram-positive anaerobes to clindamyin and metronidazole were unpredictable. The variable resistance patterns among anaerobes and the predominance of mixed anaerobic infections highlight the role of the anaerobic dignostics in case of serious pleuropulmonary diseases. Copyright 2000 Academic Press

Language: English

Document Type: Miscellaneous

Affiliations: 1: Department of Microbiology, Medical University, Sofia, Bulgaria 2: Department of Thoracic Surgery 3: Department of Thoracic Surgery, Intensive Care Unit of the University Hospital of Pulmonary Diseases “St. Sofia”, Sofia, Bulgaria

Publication date: 2000-04-01

• In this: publication
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• In this Subject: Biology
• By this author: Boyanova L. ;  Petrov D. ;  Osmanliev D. ;  Mitov I. ;  Usunova I. ;  Minchev T. ;  Goranov E. ;  Plochev M. ;  Dimitrov J.

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