Skip to main content

Determination of the Anti-Osteoporosis Drug Ipriflavone in Pharmaceutical Formulation by Stripping Voltammetric and Chromatographic Methods

Buy Article:

$45.00 + tax (Refund Policy)

Ipriflavone is a nonhormonal isoflavone derivative currently used as a bone-building agent for prevention and treatment of postmenopausal osteoporosis. Ipriflavone was reduced at the hanging mercury drop electrode in buffers of pH 211 via the consumption of 2 electrons corresponding to the reduction of the C=O double bond in the C 4 position of the analyte molecule. A fully validated square-wave adsorptive cathodic stripping (SW-AdCS) voltammetric method was described for the trace quantification of bulk ipriflavone. A linear response, with concentrations of bulk ipriflavone over the range 5 1094 107 M with a limit of detection of 1.5 109 M bulk ipriflavone, was obtained. Moreover, an LC-UV detection method was also described for determining ipriflavone. The peak area was proportional to the concentration of bulk ipriflavone over the range 1 1071 104 M with a limit of detection of 3 108 M. The described SW-AdCS voltammetric and LC methods were successfully applied for the assay of ipriflavone in iprivone tablets without interference from excipients. Accuracy and precision of both methods for determination of ipriflavone in its tablets were studied and discussed.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: Tanta University, Faculty of Science, Chemistry Department, Analytical & Electrochemistry Research Unit, 31527-Tanta, Egypt. 2: Kafr El-Sheikh University, Faculty of Education, Chemistry & Physics Department, 33516 Kafr El-Sheikh, Egypt.

Publication date: 28 May 2009

More about this publication?
  • The Journal of AOAC INTERNATIONAL publishes refereed papers and reviews in the fields of chemical, biological and toxicological analytical chemistry for the purpose of showcasing the most precise, accurate and sensitive methods for analysis of foods, food additives, supplements and contaminants, cosmetics, drugs, toxins, hazardous substances, pesticides, feeds, fertilizers and the environment available at that point in time. The scope of the Journal includes unpublished original research describing new analytical methods, techniques and applications; improved approaches to sampling, both in the field and the laboratory; better methods of preparing samples for analysis; collaborative studies substantiating the performance of a given method; statistical techniques for evaluating data. The Journal will also publish other articles of general interest to its audience, e.g., technical communications; cautionary notes; comments on techniques, apparatus, and reagents.
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Information for Advertisers
  • Journal Information
  • Masthead
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more