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Fractional Wavelet Analysis for the Simultaneous Quantitative Analysis of Lacidipine and Its Photodegradation Product by Continuous Wavelet Transform and Multilinear Regression Calibration

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Fractional wavelet transform (FWT) was applied to the original absorption spectra of lacidipine (LAC) and its photodegradation product (LACD), and the resulting FWT spectra were processed by continuous wavelet transform (CWT) and multilinear regression calibration (MLRC) for the simultaneous quantitative analysis of both products in their binary mixtures. These methods do not require any chemical separation step and chemical complex reaction to obtain a detectable signal for the degradation product. By using the Mexican hat function, 2 calibration functions for LAC and LACD were obtained by measuring the CWT transformed signals at 416.1 nm for LAC and 414.6 nm for LACD, after FWT processing of the original absorption spectra. The calibration graphs were linear in the concentration range of 5.0840.64 g/mL for LAC and 0.518.16 g/mL for LACD. The limit of detection and the limit of quantitation were found to be 0.289 and 0.956 g/mL for LAC and 0.036 and 0.118 g/mL for LACD, respectively. For comparison, the MLRC algorithm was applied to the linear regression functions for the individual drug and its photoproduct. In this approach, a set of linear regression functions was obtained from the relationship between concentrations and FWT signals in the wavelength range 411.0412.4 nm. Both methods were applied to the quantitative evaluation of LAC and LACD in laboratory and pharmaceutical samples, and produced very satisfactory results.
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Document Type: Research Article

Affiliations: 1: Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100, Tandoan, Ankara, Turkey. 2: University of Calabria, Department of Pharmaceutical Sciences, 87036 Arcavacata di Rende, Cosenza, Italy. 3: ankaya University, Faculty of Arts and Sciences, Department of Mathematics and Computer Sciences, 06530, Ankara, Turkey and National Institute for Laser, Plasma and Radiation Physics, Institute of Space Sciences, Magurele-Bucharest, PO Box MG-23, R 76911, Romania.

Publication date: 2006-11-01

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  • The Journal of AOAC INTERNATIONAL publishes refereed papers and reviews in the fields of chemical, biological and toxicological analytical chemistry for the purpose of showcasing the most precise, accurate and sensitive methods for analysis of foods, food additives, supplements and contaminants, cosmetics, drugs, toxins, hazardous substances, pesticides, feeds, fertilizers and the environment available at that point in time. The scope of the Journal includes unpublished original research describing new analytical methods, techniques and applications; improved approaches to sampling, both in the field and the laboratory; better methods of preparing samples for analysis; collaborative studies substantiating the performance of a given method; statistical techniques for evaluating data. The Journal will also publish other articles of general interest to its audience, e.g., technical communications; cautionary notes; comments on techniques, apparatus, and reagents.
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