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A Flow-Injection Biamperometric Method for Determination of Pantoprazole in Pharmaceutical Tablets

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A flow-injection biamperometric method for determination of pantoprazole (PTZ) in pharmaceutical tablets is reported for the first time. The reversible redox couples Fe3+/Fe2+, Fe(CN)6 3−/Fe(CN)6 4−, Ce4+/Ce3+, VO3 /VO2+, and I2/I were tested as indicating redox systems for biamperometric determination of PTZ in a flow-injection assembly with optimized flow parameters. The best results were obtained using VO3 /VO2+, which showed to be a selective and sensitive biamperometric indicating system for PTZ even in the presence of excipients and antioxidants that typically are found in drugs. The analytical graph was linear (r = 0.99945) in the range from 10 to 100 mg/L using 25 mmol/L VO3 as the reagent and water as the carrier stream and applying 100 mV between the 2 platinum wire electrodes. The limits of detection and quantitation were 200 and 667 μg/L, respectively, with a sensibility of calibration of 22.6 mV/mg/L. The proposed method was successfully applied to determine PTZ in commercial pharmaceutical tablets with a mean relative error of 1.60% (n = 5) and mean relative standard deviation of 3.10%. Recoveries close to 100% showed good agreement between the expected amount of PTZ in tablets (40 mg) and the results found by the application of the proposed method and demonstrated that the formulations used in the tablet compositions do not interfere in the PTZ analysis. The system had good stability, with a relative standard deviation of 3.80% for 9 sequential injections of a 60 mg/L PTZ solution. A sampling rate of about 100 samples/h was obtained.
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Document Type: Research Article

Affiliations: 1: Universidade Federal da Paraíba, Departamento de Química, CCEN, 58059-900, João Pessoa, PB, Brazil. 2: Universidade Estudual da Paraíba, Departamento de Química, CCT, 58109-790, Campina Grande, PB, Brazil. 3: Universidade Federal de Pernambuco, Departamento de Química Fundamental, CCEN, Recife, PE, Brazil. 4: Universidade Federal da Paraíba, Departamento de Química, CCEN, 58059-900, João Pessoa, PB, Brasil. 5: Universidade Federal da Bahia, Instituto de Química, Salvador, BA, Brazil. 6: Universidade do Estado da Bahia, Departamento de Ciências Exatas e da Terra, Salvador, BA, Brazil.

Publication date: 2005-07-01

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  • The Journal of AOAC INTERNATIONAL publishes refereed papers and reviews in the fields of chemical, biological and toxicological analytical chemistry for the purpose of showcasing the most precise, accurate and sensitive methods for analysis of foods, food additives, supplements and contaminants, cosmetics, drugs, toxins, hazardous substances, pesticides, feeds, fertilizers and the environment available at that point in time. The scope of the Journal includes unpublished original research describing new analytical methods, techniques and applications; improved approaches to sampling, both in the field and the laboratory; better methods of preparing samples for analysis; collaborative studies substantiating the performance of a given method; statistical techniques for evaluating data. The Journal will also publish other articles of general interest to its audience, e.g., technical communications; cautionary notes; comments on techniques, apparatus, and reagents.
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