Determination of Ciprofloxacin with a Room-Temperature Phosphorescence Flow-Through Sensor Based on Lanthanide-Sensitized Luminescence
Abstract:Direct measurement of the sensitized luminescence of the europium-ciprofloxacin chelate immobilized on a cationic exchanger was used to develop a flow-through room-temperature phosphorescence optosensor for determination of ciprofloxacin. The phosphorescent chelate is formed on-line at room temperature in a flow-injection system and is immobilized on a weakly acidic cation-exchange resin packed in a flow cell. Optimum experimental conditions and analytical performance are discussed in detail. The sensor response for ciprofloxacin was linear, from 1.5 × 10−6 to 2.0 × 10−5M with a relative standard deviation of 2.5% (n = 10) and a detection limit of 1.1 × 10−7M. The effect of possible interferences on sensor response was studied. The sensor was successfully tested for the determination of ciprofloxacin in pharmaceutical formulations.
Document Type: Research Article
Affiliations: University of Jaén, Department of Physical and Analytical Chemistry, E-23071 Jaén, Spain.
Publication date: November 1, 2002
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- The Journal of AOAC INTERNATIONAL publishes refereed papers and reviews in the fields of chemical, biological and toxicological analytical chemistry for the purpose of showcasing the most precise, accurate and sensitive methods for analysis of foods, food additives, supplements and contaminants, cosmetics, drugs, toxins, hazardous substances, pesticides, feeds, fertilizers and the environment available at that point in time. The scope of the Journal includes unpublished original research describing new analytical methods, techniques and applications; improved approaches to sampling, both in the field and the laboratory; better methods of preparing samples for analysis; collaborative studies substantiating the performance of a given method; statistical techniques for evaluating data. The Journal will also publish other articles of general interest to its audience, e.g., technical communications; cautionary notes; comments on techniques, apparatus, and reagents.
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