Simulated Aeromedical Evacuation Does Not Affect Systemic Inflammation or Organ Injury in a Murine Model of Hemorrhagic Shock
Authors: Makley, Amy T.; Belizaire, Ritha; Campion, Eric M.; Goodman, Michael D.; Sonnier, Dennis I.; Friend, Lou Ann; Schuster, Rebecca M.; Bailey, Stephanie R.; Johannigman, Jay A.; Dorlac, Warren C.; Lentsch, Alex B.; Pritts, Timothy A.
Source: Military Medicine, Volume 177, Number 8, August 2012 , pp. 911-916(6)
Abstract:ABSTRACTHemorrhagic shock is a primary injury amongst combat casualties. Aeromedical evacuation (AE) of casualties exposes patients to a hypobaric, hypoxic environment. The effect of this environment on the host response to hemorrhagic shock is unknown. In the present study, we sought to determine the effect of simulated AE on systemic inflammation and organ injury using a murine model of hemorrhagic shock. Mice underwent femoral artery cannulation and were hemorrhaged for 60 minutes. Mice were then resuscitated with a 1:1 ratio of plasma:packed red blood cells. At 1 or 24 hours after resuscitation, mice were exposed to a 5-hour simulated AE or remained at ground level (control). Serum was analyzed for cytokine concentrations and organs were assessed for neutrophil accumulation and vascular permeability. Mice in the simulated AE groups demonstrated reduced arterial oxygen saturation compared to ground controls. Serum cytokine concentrations, neutrophil recruitment, and vascular permeability in the lung, ileum, and colon in the simulated AE groups were not different from the ground controls. Our results demonstrate that mice exposed to simulated AE following hemorrhagic shock do not exhibit worsened systemic inflammation or organ injury compared to controls. The data suggest that AE has no adverse effect on isolated hemorrhagic shock.
Document Type: Research article
Publication date: 2012-08-01
- Military Medicine is the Association's official monthly journal. The objective of the Journal is to promote awareness of Federal medicine by providing a forum for responsible discussion of common ideas and problems relevant to Federal healthcare. Its mission is: To increase healthcare education by providing scientific and other information to its readers; to facilitate communication; and to offer a prestige publication for members' writings.
Military Medicine's 5-year Impact Factor: 1.061
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- By this author: Makley, Amy T. ; Belizaire, Ritha ; Campion, Eric M. ; Goodman, Michael D. ; Sonnier, Dennis I. ; Friend, Lou Ann ; Schuster, Rebecca M. ; Bailey, Stephanie R. ; Johannigman, Jay A. ; Dorlac, Warren C. ; Lentsch, Alex B. ; Pritts, Timothy A.