Safety of Chitosan Bandages in Shellfish Allergic Patients
Source: Military Medicine, Volume 176, Number 10, October 2011 , pp. 1153-1156(4)
Background: In 2005, the Office of the Surgeon General mandated that every soldier carry a HemCon bandage. Made from chitosan, a polysaccharide derived from shrimp shells, this bandage effectively stops bleeding. There are no studies reporting the safety of this bandage in shellfish allergic patients. Methods: Patients who reported shellfish allergy were recruited. Initial assessment included a detailed history, IgE skin prick testing (SPT), and serum testing to shellfish allergens. Participants who demonstrated specific shellfish IgE underwent a bandage challenge. Results: Nineteen participants were enrolled; 10 completed the study. Seven (70%) were male and the average age was 44.8 + 10 years. Nine (90%) reported a shrimp allergy history and five (50%) reported multiple shellfish allergies. All participants completing the study had positive SPT and serum IgE testing to at least one shellfish; eight (80%) had shrimp positive SPT and ten (100%) demonstrated shrimp-specific IgE. No participant had a positive SPT to chitosan powder or experienced an adverse reaction during bandage challenges. No protein bands were visualized during gel electrophoresis analysis of chitosan powder. Conclusion: All participants tolerated the HemCon bandage without reaction. This is the first study demonstrating the safety of this bandage in shellfish allergic subjects.
Document Type: Research Article
Affiliations: 1: Allergy/Immunology Service, Department of Medicine, 3851 Roger Brooke Drive, Brooke Army Medical Center, Fort Sam Houston, TX 78234. 2: Allergy/Immunology Service, Department of Medicine, 2200 Berquist Drive, Wilford Hall Medical Center, Lackland Air Force Base, TX 78236.
Publication date: 2011-10-01
- Military Medicine is the Association's official monthly journal. The objective of the Journal is to promote awareness of Federal medicine by providing a forum for responsible discussion of common ideas and problems relevant to Federal healthcare. Its mission is: To increase healthcare education by providing scientific and other information to its readers; to facilitate communication; and to offer a prestige publication for members' writings.
Military Medicine's 5-year Impact Factor: 1.061
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