Pyruvate-Fortified Fluid Resuscitation Improves Hemodynamic Stability While Suppressing Systemic Inflammation and Myocardial Oxidative Stress After Hemorrhagic Shock
Source: Military Medicine, Volume 175, Number 3, March 2010 , pp. 166-172(7)
Abstract:ABSTRACTObjectives: To determine whether controlled resuscitation with pyruvate-fortified Ringer's (PR) solution vs. conventional lactate Ringer's (LR) more effectively stabilizes mean arterial pressure (MAP) and suppresses myocardial inflammation postresuscitation. Methods: Goats were hemorrhaged (255 ± 22 ml) to lower MAP to 48 ± 1 mmHg. Next, the right femoral vessels were occluded for 90 min to model tourniquet application. Beginning at 30 min occlusion, LR or PR was infused iv at 10 ml/min for 90 min. The femoral occlusions were released at 60 min infusion. Results: At 4 h postocclusion, MAP (mmHg) was increased in PR (59 ± 4) vs. LR (47 ± 3) resuscitated goats (p < 0.05). PR also more effectively augmented circulating HCO3- and total base excess. Nitrosative stress, detected in myocardium 4 h after LR resuscitation, was suppressed by PR. Finally, PR prevented the increase in circulating neutrophils that accompanied LR resuscitation. Conclusions: Relative to LR, resuscitation with PR more effectively stabilized MAP, suppressed myocardial nitrosative stress and minimized systemic inflammation after hemorrhagic shock with hindlimb ischemia-reperfusion.
Document Type: Research article
Affiliations: 1: Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107. 2: Department of Surgery, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107. 3: Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107.
Publication date: 2010-03-01
- Military Medicine is the Association's official monthly journal. The objective of the Journal is to promote awareness of Federal medicine by providing a forum for responsible discussion of common ideas and problems relevant to Federal healthcare. Its mission is: To increase healthcare education by providing scientific and other information to its readers; to facilitate communication; and to offer a prestige publication for members' writings.
Military Medicine's 5-year Impact Factor: 1.061
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