Successful Treatment of Vancomycin-Resistant Enterococcal Ventriculitis in a Pediatric Patient with Linezolid
Authors: Maranich, Ashley M.; Rajnik, Michael
Source: Military Medicine, Volume 173, Number 9, September 2008 , pp. 927-929(3)
Abstract:Although vancomycin-resistant Enterococcus infection of the central nervous system is not common, this organism is becoming an increasing problem in nosocomial infections. We report a 17-month-old male infant with an externalized ventricular peritoneal shunt secondary to infection who subsequently developed a vancomycin-resistant Enterococcus faecium ventriculitis. This infection was successfully treated with a 28-day course of linezolid while monitoring linezolid drug levels in both the cerebral spinal fluid and serum. This case supports the use of linezolid in treating such resistant infections. However, our drug level results suggest that further investigation is needed to determine the optimal dosing of linezolid in treatment of central nervous system infection in pediatric patients.
Document Type: Research Article
Affiliations: Department of Pediatrics, F. Edward Herbert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814.
Publication date: 2008-09-01
- Military Medicine is the Association's official monthly journal. The objective of the Journal is to promote awareness of Federal medicine by providing a forum for responsible discussion of common ideas and problems relevant to Federal healthcare. Its mission is: To increase healthcare education by providing scientific and other information to its readers; to facilitate communication; and to offer a prestige publication for members' writings.
Military Medicine's 5-year Impact Factor: 1.061
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