Mupirocin Resistance Screening of Methicillin-Resistant Staphylococcus aureus Isolates at Madigan Army Medical Center
Source: Military Medicine, Volume 173, Number 6, June 2008 , pp. 604-608(5)
Abstract:Mupirocin is an antibiotic used for eradication and infection control of methicillin-resistant Staphylococcus aureus (MRSA). Mupirocin binds to the bacterial isoleucyl tRNA synthetase, thus disrupting bacterial protein synthesis. Four hundred nine MRSA clinical isolates collected in 2006 and 2007 at Madigan Army Medical Center were screened for mupirocin resistance by E test and polymerase chain reaction; 7 MRSA isolates (1.7%) were found to be fully resistant to mupirocin (minimum inhibitory concentration [MIC] by E test: >1,024 μg/mL), 10 isolates (2.4%) had MIC values of 1 to 32 μg/mL, while 392 MRSA isolates (95.9%) had MIC values of <1 μg/mL. No trend of increased mupirocin resistance was found when compared with subsequent years. These results show that mupirocin remains a valid infection control measure due to its unique mechanism of action and the high susceptibility rate of MRSA isolates. In addition, rapid screening by polymerase chain reaction of MRSA shows promise in assessing the fully resistant mupirocin phenotype.
Document Type: Research Article
Affiliations: 1: Department of Pathology and Area Laboratory Services, Madigan Army Medical Center, 9840 Fitzsimmons Drive, Fort Lewis, WA 98431. 2: Department of Pediatric Infectious Disease, Madigan Army Medical Center, 9840 Fitzsimmons Drive, Fort Lewis, WA 98431.
Publication date: June 2008
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Military Medicine is the Association's official monthly journal. The objective of the Journal is to promote awareness of Federal medicine by providing a forum for responsible discussion of common ideas and problems relevant to Federal healthcare. Its mission is: To increase healthcare education by providing scientific and other information to its readers; to facilitate communication; and to offer a prestige publication for members' writings.
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