The endosomal epsilon-coatomer protein is involved in human adenovirus type 5 internalisation
Authors: Jeney, Cs.; Banizs, Boglárka ; Dobay, Orsolya ; et al.
Source: Acta Veterinaria Hungarica, Volume 50, Number 4, 16 October 2002 , pp. 481-489(9)
Publisher: Akademiai Kiado
Abstract:The effects of bafilomycin A1 and of the reduced level of endosomal epsilon-COP (coatomer protein) on the infectivity of human adenovirus type 5 were investigated in Coxsackie adenovirus receptor- (CAR-) transfected Chinese hamster ovary (CHO) cells. The endosomal proton pump inhibitor bafilomycin A1 was able to cause only partial inhibition. Using ldlF cells (an epsilon-COP thermosensitive mutant CHO cell line) the reduction of epsilon-COP level also had partial inhibitory effect. Based on these results and comparing them to existing models of the adenovirus entry, we propose a refined model in which there are two pathways of adenoviral entry: the first one involves the epsilon-COP as the downstream effector of the acidification and can be blocked by bafilomycin A1 and the second one is a pH-independent pathway.
Document Type: Research Article
Publication date: October 16, 2002
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