Tumour suppressor gene p53 mutation in a case of haemangiosarcoma of a dog

Authors: B. Mayr; S. Zwetkoff; G. Schaffner; et al.

Source: Acta Veterinaria Hungarica, Volume 50, Number 2, 3 May 2002 , pp. 157-160(4)

Publisher: Akademiai Kiado

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Abstract:

Haemangiosarcomas of dogs were analysed by molecular genetic techniques. Regions of the tumour suppressor gene p53, including the well-known tumour hot spots (codons 175, 245, 248, 249, 273 and 282) were screened. A 24 bp deletion was detected in exon 5 of the gene.

Keywords: Haemangiosarcoma; mutation; dog; p53; spleen

Document Type: Research article

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