Skip to main content


Buy Article:

$20.64 plus tax (Refund Policy)

Disposition kinetics and urinary excretion of ceftriaxone were investigated in healthy crossbred calves after its single intravenous administration (10 mg kg –1 ). Based on kinetic parameters, an appropriate dosage regimen of ceftriaxone in calves was calculated. The peak plasma level of ceftriaxone at 1 min was 84.0 ± 1.55 µg ml –1 which declined to 0.43 ± 0.05 µg ml –1 at 8 h. The value of elimina-tion half-life (t1/2b ), volume of distribution Vd (area) and total body clearance (ClB) were 4.39 ± 0.63 h, 1.91 ± 0.19 L kg –1 and 0.31 ± 0.01 L kg –1 h –1 , respectively. Approximately 41 per cent of total administered drug was recovered in the urine within 24 h of its administration. The plasma protein binding of ceftriaxone was found to be concentration dependent with an overall mean of 38.55 per cent. The binding capacity of ceftriaxone to plasma proteins and the dissociation rate con-stant of protein-drug complex were 20.1 × 10 –8 ± 18.4 × 10 –8 mole g –1 and 1.07 × 10 –6 ± 0.52 × 10 –6 mole, respectively. An appropriate intravenous dosage regimen of ceftriaxone in cattle would be 12 mg kg –1 repeated at 24 h.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: calf; ceftriaxone; disposition kinetics; dosage regimen; urinary excretion

Document Type: Research Article

Publication date: 1999-10-21

More about this publication?
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more