IngentaConnect Cost Effectiveness of Esomeprazole Compared with Omeprazole in th...

Abstract:

Background: Clinical studies have demonstrated that esomeprazole is superior to omeprazole for the acute treatment of reflux oesophagitis.

Objective: To compare the cost effectiveness of esomeprazole 40mg once daily with omeprazole 20mg once daily in patients with reflux oesophagitis.

Methods: Pooled data were used from three 8-week clinical trials comparing the efficacy and safety of esomeprazole 40mg once daily and omeprazole 20mg once daily for the acute treatment of reflux oesophagitis. A simple decision analysis model, using UK direct medical costs, compared the cost effectiveness of the two treatments. Healing probabilities derived from the clinical studies using the Life Table method were used to estimate the effectiveness and cost of treating 100 patients with reflux oesophagitis. Patient management assumptions were based on a clinical management survey involving 25 UK physicians.

Perspective: UK National Health Service.

Results: After 4 weeks' therapy, the Life Table estimated the oesophageal healing rate to be 77.7% in esomeprazole 40mg once-daily recipients (n = 2446), compared with 67.6% in omeprazole 20mg once-daily recipients (n = 2431; p < 0.001). The corresponding values after 8 weeks' treatment were 93.4% and 86.2%, respectively (p < 0.001). The model predicted that when considering healing probabilities over 8 weeks, esomeprazole 40mg once daily produced total direct cost savings of £1290 (14%) when compared with omeprazole 20mg once daily. When considering the cost of treating patients who had failed treatment (defined as patient not healed as assessed by endoscopy) after 8 weeks, the cost advantage for esomeprazole was even greater.

Conclusion: Esomeprazole 40mg once daily is cost effective compared with omeprazole 20mg once daily in the acute treatment of patients with reflux oesophagitis; esomeprazole provides greater effectiveness at a lower cost.

Keywords: Cost effectiveness; Esomeprazole, therapeutic use; Omeprazole, therapeutic use; Pharmacoeconomics; Reflux oesophagitis, treatment

Document Type: Original article

Affiliations: 1: AstraZeneca R&D Mölndal, Mölndal, Sweden 2: AstraZeneca UK Ltd, Kings Langley, Hertfordshire, United Kingdom 3: Department of Gastroenterology, City General Hospital, Stoke-on-Trent, Staffordshire, United Kingdom

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Cost Effectiveness of Esomeprazole Compared with Omeprazole in the Acute Treatment of Patients with Reflux Oesophagitis in the UK