IngentaConnect Cost Effectiveness of Ciprofloxacin plus Metronidazole versus Imi...

Abstract:

Objective: To compare the cost effectiveness of sequential intravenous (IV) to oral ciprofloxacin plus metronidazole (CIP/MTZ IV/PO) with that of IV ciprofloxacin plus IV metronidazole (CIP/MTZ IV) and IV imipenem-cilastatin (IMI IV) in patients with intra-abdominal infections.

Design and participants: Patients enrolled in a double-blind randomised clinical trial were eligible for inclusion into this cost-effectiveness analysis. Decision analysis was used to characterise the economic outcomes between groups and provide a structure upon which to base the sensitivity analyses. 1996 cost values were used throughout.

Setting: The economic perspective of the analysis was that of a hospital provider.

Main outcome measures and results: Among 446 economically evaluable patients, 176 could be switched from IV to oral administration. The 51 patients randomised to CIP/MTZ IV/PO who received active oral therapy had a success rate of 98%, mean duration of therapy of 9.1 days and mean cost of $US7678. There were 125 patients randomised to either CIP/MTZ IV or IMI IV who received oral placebo while continuing on active IV antibacterials; their success rate was 94%, mean duration of therapy was 10.1 days and mean cost was $US8774 (p = 0.029 vs CIP/MTZ IV/PO). Of the 270 patients who were unable to receive oral administration, 97 received IMI IV and had a success rate of 75%, mean duration of therapy of 13.8 days and a mean cost of $US12 418, and 173 received CIP/MTZ IV and had a success rate of 77%, mean duration of therapy of 13.4 days and mean cost of $US12 219 (p = 0.26 vs IMI IV).

Conclusions: In patients able to receive oral therapy, sequential IV to oral treatment with ciprofloxacin plus metronidazole was cost effective compared with full IV courses of ciprofloxacin plus metronidazole or imipenem-cilastatin. In patients unable to receive oral therapy, no difference in mean cost was found between IV imipenem-cilastatin or IV ciprofloxacin plus IV metronidazole.

Keywords: Pharmacoeconomics; Ciprofloxacin, therapeutic-use; Metronidazole, therapeutic-use; Imipenem.cilastatin, therapeutic-use; Intra-abdominal-infections, treatment; Sequential-therapy; Intravenous; Oral; Randomised-controlled-trials; Cost-effectiveness; Resource-use; Antibacterials, therapeutic-use

Language: English

Document Type: Original article

Affiliations: 1: Clinical Pharmacokinetics Laboratory, Millard Fillmore Suburban Hospital, Buffalo, New York, USA 2: Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA *

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Cost Effectiveness of Ciprofloxacin plus Metronidazole versus Imipenem-Cilastatin in the Treatment of Intra-Abdominal Infections