Inpharma

Molecular mechanism of antibiotic resistance uncovered
pp. 1-1(1)

NICE balance between impartiality and compassion needed
pp. 2-2(1)

Bevacizumab plus paclitaxel/carboplatin is predicted to become the clinical gold-standard for advanced ovarian cancer in 2011
pp. 2-2(1)

Posaconazole prophylaxis pays off
pp. 3-4(2)

Antimalarial subsidy looking good in Tanzania
pp. 4-4(1)

Most US consumers with chronic conditions (86%) would `always' adhere to their prescription medicines if co-pays were waived or reduced
pp. 4-4(1)

Darapladib has a hearty effect on Lp-PLA2 activity
pp. 5-5(1)

Fluoxetine may put a smile on the faces of patients with RRMS
pp. 5-5(1)

"Challenges in biomedical sciences have become so complex that no single research-based pharmaceutical company is able to face them alone"
pp. 5-5(1)

A fixed low-dose morphine/oxycodone combination [Q 8003IR] has demonstrated statistically significant analgesic activity at all doses
pp. 5-5(1)

Niacin/simvastatin a practical combo in dyslipidaemia
pp. 6-6(1)

The thrombin inhibitor NU 172 is associated with a rapid onset and offset of anticoagulation and is well tolerated.
pp. 6-6(1)

Novel meningococcal conjugate vaccine activity promising
pp. 6-6(1)

PF 03187207: eyeing silver lining
pp. 6-6(1)

Iclaprim can ASSIST in the fight against cSSSIs
pp. 7-8(2)

The oral cyclophilin inhibitor DEBIO 025 has a "significant antiviral effect" against different genotypes of the hepatitis C virus
pp. 8-8(1)

Aflibercept [vascular endothelial growth factor Trap-Eye] appears to be effective in the neovascular form of age-related macular degeneration
pp. 8-8(1)

Addition of fluvastatin to a calcium channel antagonist reduces acetylcholine-induced coronary spasm
pp. 9-9(1)

Rosiglitazone increases exercise capacity in patients with type 2 diabetes mellitus
pp. 9-9(1)

"Low-exposure tacrolimus with everolimus was not associated with any reduction in efficacy compared to standard-exposure tacrolimus"
pp. 9-9(1)

Linezolid comparable to vancomycin for MRSA SSTI
pp. 9-9(1)

Rituximab is not effective for the treatment of systemic lupus erythematosus
pp. 9-9(1)

Other news from ECCMID
pp. 11-11(1)

Corticosteroids not life saving for kids with bacterial meningitis
pp. 12-12(1)

Placebo effect associated with cumulative benefit
pp. 12-12(1)

Ethinylestradiol plus drospirenone appears to be effective in the treatment of moderate acne vulgaris
pp. 12-12(1)

Amlodipine/valsartan combo superior to amlodipine/atenolol
pp. 13-13(1)

Anastrozole promotes growth in boys with GH deficiency
pp. 13-13(1)

2nd gen antidepressants make the grade in social phobia
pp. 13-13(1)

Doripenem is as effective as imipenem for ventilator-associated pneumonia
pp. 13-13(1)

When to stART for HIV? SMART answer: immediately
pp. 14-14(1)

Octreotate-Lu-177-DOTA-Tyr-3 appears to deliver a survival benefit to patients with gastroenteropancreatic neuroendocrine tumours
pp. 14-14(1)

Genetic variation may alter the efficacy of irinotecan-containing therapies in patients with advanced colorectal cancer.
pp. 14-14(1)

Corticosteroid avoidance possible after liver transplantation?
pp. 14-14(1)

High-dose valsartan for prevention of in-stent restenosis
pp. 15-15(1)

Iobenguane [131I-metaiodobenzylguanidine] improves symptoms in patients with neuroendocrine tumours
pp. 15-15(1)

Irbesartan/hydrochlorothiazide superior in hypertension
pp. 15-15(1)

Ibritumomab tiuxetan Y-90 consolidation viable in NHL
pp. 15-15(1)

In a case-control analysis, use of thiazolidinediones or metformin was associated with a lower risk of developing psoriasis.
pp. 16-16(1)

Nicotine replacement, nortriptyline for smokers: time to quit?
pp. 16-16(1)

It's all in the timing for corticosteroids in ARDS
pp. 16-16(1)

IV nitroglycerin reduces BP faster and to a greater extent than sublingual nifedipine in patients with pre-eclampsia
pp. 16-16(1)

Therapeutic drug monitoring beneficial in colorectal cancer
pp. 17-17(1)

Immunosuppressive therapy (IST) is a promising option for myelodysplastic syndromes (MDS) showing both a moderate response rate
pp. 17-17(1)

Molgramostim enhances the efficacy of rituximab in patients with relapsed or progressive follicular lymphoma
pp. 17-17(1)

Ovulatory response to metformin appears to be dependent upon a single nucleotide polymorphism in the STK11 gene.
pp. 17-17(1)

Lamivudine prophylaxis prevents hep B reactivation
pp. 17-17(1)

Risedronic acid prevents bone loss in postmenopausal women with breast cancer, with or without aromatase inhibitor (AI) therapy,
pp. 18-18(1)

Outpatient administration of IV diuretics is effective for the treatment of acute decompensated heart failure
pp. 18-18(1)

Moxifloxacin has the X factor for odontogenic infection
pp. 18-18(1)

Oral S-1 in conjunction with oxaliplatin may be an effective treatment for metastatic colorectal cancer with an acceptable safety profile
pp. 18-18(1)

Second-line immunosuppression with leflunomide appears to be beneficial in patients with Crohn's disease
pp. 18-18(1)

US researchers report positive findings with oseltamivir in lung transplant recipients with influenza virus infections.
pp. 19-19(1)

The efficacy of tranexamic acid for reducing bleeding after cardiopulmonary bypass (CPB) surgery is affected by patient PAI-1 genotype
pp. 19-19(1)

Valproate effective maintenance therapy in bipolar disorder
pp. 19-19(1)

Therapeutic phlebotomy to induce iron depletion enhances the efficacy of interferon in patients with chronic hepatitis C
pp. 19-19(1)

Statins reduce cholesterol levels in a normal care setting
pp. 19-19(1)

Vaginal administration of misoprostol has a significant effect on cervical ripening in premenopausal women undergoing operative hysteroscopy
pp. 20-20(1)

CYP2B6 516G→T(*6) variance alters efavirenz metabolism allowing for a reduction in dosage
pp. 20-20(1)

Use of low-dose terlipressin plus albumin improves renal function in patients with cirrhosis and type 1 hepatorenal syndrome
pp. 20-20(1)

Greater doses of carvedilol are required in children and adolescents with heart failure (HF) to achieve the same exposure as adults.
pp. 20-20(1)

ACE inhibitors and β-blockers significantly reduce plasma homocysteine levels in patients with essential hypertension
pp. 20-20(1)

ADE trigger tool uncovers paediatric adverse events
pp. 21-21(1)

Heparin saga rolls on
pp. 21-21(1)

Inhalation of insulin using the AERx insulin Diabetes Management System (iDMS) does not appear to be associated with lung cancer
pp. 21-21(1)

Exenatide and acute pancreatitis
pp. 22-22(1)

From January 2006 to November 2007, the French Pharmacovigilance Centers received ten reports of strontium ranelate-associated DRESS syndrome
pp. 22-22(1)

Generic epoprostenol approved in US.
pp. 22-22(1)

Mylan Pharmaceuticals' ANDA for trandolapril approved.
pp. 22-22(1)

Lubiprostone approved for IBS with constipation in US women.
pp. 22-22(1)

Cinryze approval recommended by US FDA committee.
pp. 22-22(1)

Glenmark launches sertaconazole in India.
pp. 22-22(1)

Febuxostat receives marketing authorisation in the EU.
pp. 22-22(1)

Niacin/laropiprant [MK0524A] not approvable in US.
pp. 23-23(1)

Salmeterol/fluticasone propionate approved for COPD exacerbations in US.
pp. 23-23(1)

Triptorelin delivery system approved in the US.
pp. 23-23(1)

Sinapultide approved in the US.
pp. 23-23(1)