Secondary Hypertension and Essential Thrombocythaemia: A Clinical Case Report

Authors: >Rosa Maria Bruno,; Mazzi, Valeria; >Irene di Paco,; Ghiadoni, Lorenzo; Salvetti, Antonio; Taddei, Stefano

Source: High Blood Pressure & Cardiovascular Prevention, Volume 17, Number 1, 1 March 2010 , pp. 49-52(4)

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Abstract:

A 26-year-old man visited the Outpatient Hypertension Unit, Department of Internal Medicine, University of Pisa, Italy, for uncontrolled hypertension under a two-drug antihypertensive treatment. He had been previously diagnosed with essential thrombocythaemia and had been prescribed aspirin (acetylsalicylic acid) 100 mg/day since he was 20 years old, with a stable platelet count of about 700 000-800 000. High blood pressure lasted 3 months and was treated with lisinopril 20 mg/day. One month before the visit he had an acute coronary syndrome, with normal coronary angiogram, and clopidogrel 75 mg/day and amlodipine 5 mg/day were added at discharge. At the Hypertension Unit, a bilateral renal artery stenosis was diagnosed, accompanied by cardiac and renal target organ damage. Moreover, a total occlusion of the right carotid artery was found. The patient underwent bilateral percutaneous renal angioplasty with stent placement. He was discharged with interferon-α-2b, aspirin and warfarin and with no antihypertensive therapy, having blood pressure values of 100/70 mmHg. A few months later he became hypertensive again and lisinopril 20 mg/day was prescribed, while platelet count was reduced to 500 000. Nine months later he died of a sudden death.

Received for publication 20 January 2010; accepted for publication 25 February 2010.

Keywords: Hypertension, treatment; Secondary-hypertension, treatment; Thrombocytosis, treatment

Document Type: Case report

Affiliations: 1: Department of Internal Medicine, University of Pisa, Pisa, Italy

Publication date: 2010-03-01