Oral isotretinoin is first-line treatment in severe nodular acne, with other agents indicated as second-line or adjunctive therapy

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In this Subject: Pharmacology

Source: Drugs & Therapy Perspectives, Volume 27, Number 8, 1 August 2011 , pp. 11-14(4)

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Abstract:

Oral isotretinoin is the first-line treatment option for severe nodular acne. If isotretinoin is contraindicated or poorly tolerated, combination therapy with an oral antibacterial, benzoyl peroxide and a topical retinoid is recommended. Other options include oral anti-androgens and corticosteroids.

Keywords: Acne; Adapalene; Antiandrogens; Antibacterials; Benzoyl-peroxide; Corticosteroids; Cyproterone; Doxycycline; Isotretinoin; Minocycline; Nodulocystic-acne; Oral-contraceptives; Oxytetracycline; Retinoids; Spironolactone; Tazarotene; Tetracycline; Treatment-algorithms; Tretinoin