@article {Moen:2006:0012-6667:883,
	author = "Moen, Marit D.",
	author = "Keating, Gillian M.",
	title = "Sumatriptan Fast-Disintegrating/Rapid-Release Tablets",
	journal = "Drugs",
	volume = "66",
	year = "2006",
	abstract = "&#9652; Sumatriptan is a serotonin 5-HT<SUB>1B/1D</SUB> receptor agonist that is used for the acute treatment of migraine attacks. A new fast-disintegrating/rapid-release sumatriptan tablet (sumatriptan FDT/RRT) has been developed with the goal of speeding absorption and onset of effect compared with standard sumatriptan tablets.<P></P>&#9652; Bioequivalence of sumatriptan FDT/RRT tablets to standard sumatriptan tablets was established in healthy volunteers. Initial data suggest that sumatriptan FDT/RRT tablets may disintegrate faster and get emptied from the stomach faster than standard sumatriptan tablets.<P></P>&#9652; In a randomised, double-blind, multicentre, early intervention trial in adults with mild migraine, significantly more sumatriptan FDT/RRT 50 and 100mg recipients than placebo recipients were pain free or migraine free 2 hours after receiving study medication.<P></P>&#9652; Compared with placebo, pain relief was significantly greater with sumatriptan FDT/RRT 100mg at 25 and 17 minutes following administration, and with sumatriptan FDT/RRT 50mg at 50 and 30 minutes following administration, in two randomised, double-blind, multicentre trials in adults with moderate to severe migraine.<P></P>&#9652; Sumatriptan FDT/RRT tablets were generally well tolerated; the tolerability profile was similar to that reported for standard sumatriptan tablets in other studies.",
	pages = "883-890(8)",
	url = "http://www.ingentaconnect.com/content/adis/dgs/2006/00000066/00000006/art00018"
}