Ropivacaine: A Review of its Use in Regional Anaesthesia and Acute Pain Management

Authors: Simpson, Dene; Curran, Monique P.; Oldfield, Vicki; Keating, Gillian M.

Source: Drugs, Volume 65, Number 18, 2005 , pp. 2675-2717(43)

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Abstract:

Ropivacaine (Naropin^®) is the pure S(−)-enantiomer of propivacaine, and is a long-acting amide local anaesthetic agent, eliciting nerve block via reversible inhibition of sodium ion influx in nerve fibres.

Ropivacaine is a well tolerated regional anaesthetic effective for surgical anaesthesia as well as the relief of postoperative and labour pain. The efficacy of ropivacaine is similar to that of bupivacaine and levobupivacaine for peripheral nerve blocks and, although it may be slightly less potent than bupivacaine when administered epidurally or intrathecally, equi-effective doses have been established. Clinically adequate doses of ropivacaine appear to be associated with a lower incidence or grade of motor block than bupivacaine. Thus ropivacaine, with its efficacy, lower propensity for motor block and reduced potential for CNS toxicity and cardiotoxicity, appears to be an important option for regional anaesthesia and for the management of postoperative and labour pain.

Keywords: Acute pain; Adis Drug Evaluations; Labour pain; Postoperative pain; Regional anaesthesia; Ropivacaine

Document Type: Research article

Affiliations: 1: Adis International Limited, Auckland, New Zealand

Publication date: 2005-01-01