Oxycodone/Ibuprofen Combination Tablet: A Review of its Use in the Management of Acute Pain

Authors: Oldfield, Vicki¹; Perry, Caroline M.

Source: Drugs, Volume 65, Number 16, 2005 , pp. 2337-2354(18)

Publisher: Adis International

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Abstract:

Oxycodone/ibuprofen 5mg/400mg (Combunox™) is an oral fixed-dose combination tablet with analgesic, anti-inflammatory and antipyretic properties. It is approved in the US for the short-term (up to 7 days) management of acute, moderate-to-severe pain and is the first and only fixed-dose combination containing ibuprofen and oxycodone.

A single dose of oxycodone/ibuprofen 5mg/400mg provided better analgesia than low-dose oxycodone or ibuprofen administered alone in most trials and appears to be more effective than a single dose of some other fixed-dose combination analgesics. It is generally well tolerated after single or multiple doses and short-term use is not expected to produce any of the serious adverse effects typically associated with the long-term use of opioids or NSAIDs. Thus, oxycodone/ibuprofen 5mg/400mg is an effective, convenient treatment option for the short-term management of acute, moderate-to-severe pain.

Keywords: Acute pain; Adis Drug Evaluations; Oxycodone/ibuprofen

Document Type: Research article

Affiliations: 1: Adis International Limited, Auckland, New Zealand

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