IngentaConnect Montelukast

Abstract:

utrif Montelukast is a selective antagonist of the leukotriene D (LTD) receptor. In patients with asthma, montelukast 5 to 250 mg/day attenuated LTD-induced bronchoconstriction and, at a dosage of 10mg, significantly reduced early and late airway response to allergen (dust mite extract) relative to placebo.

utrif In studies evaluating the effects of various dosages of montelukast on exercise-induced bronchoconstriction the optimal dose of the drug was found to be 10mg.

utrif Montelukast 10 mg/day controlled asthma significantly more effectively than placebo in a 3-month randomised double-blind study. In a 9-month open extension of this trial, during which patients were randomised to treatment with montelukast 10 mg/day or beclomethasone (400 µg/day), daytime symptom score and beta -agonist use decreased to a similar extent in each group.

utrif In a further study, treatment with montelukast 10 mg/day permitted clinically significant tapering of corticosteroid dosage in patients with stable asthma.

utrif Montelukast (5 mg/day) has also demonstrated efficacy in childhood asthma.

utrif The tolerability profile of montelukast was similar to that of placebo in placebo-controlled clinical trials in adults and children; the most common adverse event was headache.

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