Acute Kidney Injury in a Patient with Melanuria, Diffuse Melanosis, and Metastatic Malignant Melanoma

Authors: Gambichler, Thilo¹; Stücker, Markus¹; Kerner, Katja¹; Weiner, Stefan²; Waldherr, Rüdiger³; Altmeyer, Peter¹; Kreuter, Alexander¹

Source: American Journal of Clinical Dermatology, Volume 9, Number 4, 2008 , pp. 267-270(4)

Publisher: Adis International

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Abstract:

Diffuse melanosis with melanuria is a rare complication of metastatic malignant melanoma that is associated with a very poor prognosis. Acute kidney injury secondary to melanuria has not been reported previously. We describe a patient with malignant melanoma, diffuse melanosis, and melanuria who developed acute kidney injury that was clinically indicated by an increase in urinary excreted metabolites in the serum. Histopathologic examination of kidney tissue revealed damage to tubules associated with disseminated intra-tubular melanin deposits. Diffuse melanosis with melanuria may lead to morphologic and functional kidney changes and warrants careful monitoring of kidney function in affected malignant melanoma patients.

Keywords: Malignant melanoma; Melanosis; Renal impairment

Document Type: Research article

Affiliations: 1: 1 Department of Dermatology, Ruhr-University Bochum, Bochum, Germany 2: 2 Center for Dialysis, Nephrology, and Rheumatology, II Medical Department, Trier, Germany 3: 3 Private Practice for Pathology and Cytology, Heidelberg, Germany

Publication date: 2008-01-01